Publi­ka­tio­nen von
ISAR Bioscience

Fort­schritte in Medi­zin und For­schung, Medi­en­be­richte, Publi­ka­tio­nen, Ver­an­stal­tun­gen: Wir hal­ten Sie auf dem Laufenden.

Publi­ka­tio­nen von ISAR Bioscience

Fort­schritte in Medi­zin und For­schung, Medi­en­be­richte, Publi­ka­tio­nen, Ver­an­stal­tun­gen: Wir hal­ten Sie auf dem Laufenden.

  • All
  • Alz­hei­mer
  • FIA-CIA
  • GPCR
  • Immun­the­ra­pien
  • LNPs
  • SARS-CoV2
  • ZELL-ALZ
Klüp­fel J, Koros RC, Dehne K, Unge­rer M, Würstle S, Maut­ner J, Feu­er­herd M, Prot­zer U, Hay­den O, Els­ner M, Sei­del M. 
2021
Auto­ma­ted, flow-based che­mi­lumi­ne­s­cence micro­ar­ray immu­n­o­as­say for the rapid mul­ti­plex detec­tion of IgG anti­bo­dies to SARS-CoV-2 in human serum and plasma (CoV­Ra­pid CL-MIA)
Anal Bio­anal Chem. 2021:1-14

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Wen­hart C, Holt­hoff HP, Rei­mann A, Li Z, Faß­ben­der J, Unge­rer M.
2021
A fruc­to­sy­l­a­ted pep­tide deri­ved from a col­la­gen II T cell epi­tope for long-term tre­at­ment of arthri­tis (FIA-CIA) in mice.
Sci­en­ti­fic Reports; 30;11(1):17345. doi: 10.1038/s41598-021-95193-2

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Richard­son JR, Götz R, Mayr V, Lohse MJ, Holt­hoff HP, Unge­rer M.
2022
SARS-CoV2 wild type and mutant spe­ci­fic humo­ral and T cell immu­nity is supe­rior after vac­ci­na­tion than after natu­ral infection.
PLoS One 17(4):e0266701

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Venit T, Bla­vier J, Maseko SB, Shu S, Espada L, Breu­nig C, Holt­hoff HP, Des­bor­des SC, Lohse M, Espo­sito G, Twi­zere JC, Per­ci­palle P 
2024
Nano­body against SARS-CoV-2 non-struc­­tu­ral pro­tein Nsp9 inhi­bits viral repli­ca­tion in human air­way epithelia.
Mol Ther Nucleic Acids 35(3):102304

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Mob­ach S, Berg­kamp ND, Ma Z, Hase­la­ger MV, Anbuhl SM, Jur­ri­ens D, van den Bor J, Wang Z, Crud­den C, Roos JL, Perez Alme­ria CV, Boer­gonje RA, Lohse MJ, Bosma R, Elde­ring E, Side­rius M, Wu W, Spaar­ga­ren M, Tonino SH, Kater AP, Smit MJ, Heu­kers R 
2025
Dis­rup­tion of con­sti­tu­tive CXCR4 oli­go­mers impairs onco­ge­nic pro­per­ties in lym­phoid neoplasms.
Proc Natl Acad Sci USA 122(24):e2424186122

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Niz­zolo S, Zan­zoni S, Holt­hoff HP, Gira­sole M, Gru­ber R, Len­hart D, Yates E, Guer­rini M, Ber­tini S 
2026
Pent­o­san Poly­sul­fate and Hepa­rin Exhi­bit Com­pa­ra­ble Inter­ac­tions with Plate­let Fac­tor 4, Sug­gest­ing a Poten­tial Risk of Thrombocytopenia.
ACS Omega. 11(4):6442-6451

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Poliez­haieva T, Li Y, Chaud­hari PS, Isildak U, Alonso-Per­nas P, Valen­tim IS, Su F, Espada L, Bayar M, Fu L, Koe­berle A, Döner­taş HM, Ermo­laeva MA.
2026
Aging-asso­cia­­ted decline of phos­pha­ti­dyl­cho­line syn­the­sis is a mal­leable trig­ger of natu­ral mito­chon­drial aging.
Nat Com­mun. 17(1):3589

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Lohse MJ, Bock A, Zac­colo M 
2024
G Pro­tein-Cou­­p­led Recep­tor Signal­ing: New Insights Define Cel­lu­lar Nanodomains.
Annu Rev Phar­ma­col Toxi­col. 64:387-415

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Sirbu A, Bathe-Peters M, Kumar JLM, Inoue A, Lohse MJ, Anni­bale P 
2024
Cell swel­ling enhan­ces ligand-dri­­ven β-adr­e­ner­­gic signaling.
Nat Com­mun. 15(1):7822

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Sohail I, Lau­rin SA, Kleinau G, Chuni­lal V, Mor­ton A, Brenlla A, Kagiali ZCU, Blouin MJ, Tello JA, Beck-Sickin­ger AG, Lohse MJ, Schee­rer P, Bou­vier M, McCor­mick P, Anni­bale P, Bie­ber­mann H 
2025
MRAP2 modi­fies the signal­ing and oli­go­me­riza­tion state of the mela­­no­­cor­­tin-4 receptor.
Nat Com­mun. 16(1):8324

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Schihada H, Shahr­aki A, Turku-Met­sä­nen A, Rath M, Wirth L, Nemec K, Tse­le­pli H, Heit­zer L, Val­las­ter B, Fadel M, Schulte G, Hil­ger D, Pockes S, Lohse MJ, Kolb P 
2026
GPR3 Ligands Dis­co­vered through Com­bi­ned Vir­tual and Con­for­ma­tio­nal Bio­­­sen­­sor-Based Screening.
J Am Chem Soc. 148(19):20285-20295

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Gon­zá­lez-Gal­lego J, Todo­rov-Völ­gyi K, Mül­ler SA, Antes­ber­ger S, Todo­rov MI, Malik R, Gri­malt-Mirada R, Gon­çal­ves CC, Schif­fe­rer M, Kis­lin­ger G, Weis­heit I, Lind­ner B, Cru­sius D, Kroe­ger J, Borri M, Erturk A, Nel­son M, Mis­geld T, Lich­ten­tha­ler SF, Dich­gans M, Paquet D 
2026
A fully iPS-cell-deri­­ved 3D model of the human blood-brain bar­rier for explo­ring neu­ro­vas­cu­lar dise­ase mecha­nisms and the­ra­peu­tic interventions.
Nature Neu­ro­sci. 29(2):479-492

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Hass Y, Kniep J, Hof­f­rich­ter A, Mar­soner F, Eşi­yok N, Gas­pa­rotto M, Xing L, Loco Detto Gava MP, Artioli A, Guida C, Meuth SG, Hutt­ner WB, Jabali A, Heide M, Lade­wig J
2025
ARHGAP11A main­ta­ins cor­ti­cal pro­ge­ni­tor iden­tity through RHOA-ROCK signal­ing during human brain development.
Cell Rep. 44(12):116599

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Tho­mas R, Jacoby PS, De Faveri C, Derieux C, Lie­bing A-D, Mel­kes B, Mar­tini H-J, Ber­mu­dez M, Stäu­bert C, Lohse MJ, Coin I, Bock A 
2026
Ligand-spe­ci­­fic acti­va­tion tra­jec­to­ries dic­tate GPCR signal­ling in cells
Nature 650:1053-1062

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Dan­nert A, Klimmt J, Car­doso Gon­çal­ves C, Cru­sius D, Paquet D 
2023
Repro­du­ci­ble and sca­lable dif­fe­ren­tia­tion of highly pure cor­ti­cal neu­rons from human indu­ced plu­ri­po­tent stem cells.
STAR Pro­toc. 4(2):102266

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Kral­ler M, Faß­ben­der J, Jabali A, Kroe­ger J, Fink B, Pop­per B, Unge­rer M, Christl­meier MA
2025
Novel fully human high-affi­­nity anti-TREM2 anti­body shows effi­cacy in cli­ni­cally rele­vant Alzheimer’s mouse model.
Alzheimer´s Rese­arch & The­rapy 17, 114

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Ammon T, Zeit­räg J, Mayr V, Bene­di­cic M, Holt­hoff HP, Unge­rer M
2025
Citrul­li­na­ted auto­an­­ti­­gen-spe­ci­­fic T and B lym­pho­cytes in rheu­ma­toid arthri­tis: focus on fol­li­cu­lar T hel­per cells and expan­sion by coculture
ACR Open Rheu­ma­tol. 7(1):e11785

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Zeit­räg J, Bene­di­cic M, Wolf J, Ammon T, Mayr V, Holt­hoff HP, Kahaly GJ, Unge­rer M 
2025
Inflamm­a­tory and tole­ro­ge­nic den­dri­tic cells and T lym­pho­cytes in Gra­ves‘ thy­ro­idal and orbi­tal disease
Bio­chim Bio­phys Acta Mol Basis Dis. 1871(5):167747

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