Work­ing together for the RNA Medi­cine of the Future

The BASE-Lipid future pro­ject (“bio­de­grad­able, safe, and effi­cient spe­cialty lip­ids”), coordin­ated by ISAR Bioscience, received a total of nearly 13 mil­lion euros in fund­ing from the Fed­eral Min­istry for Eco­nomic Affairs. These novel lip­ids are designed not only to effi­ciently and stably encap­su­late RNA drugs and to release them spe­cific­ally in cer­tain organs, but also to be bio­de­grad­able and par­tic­u­larly well-tol­er­ated. The net­work includes the com­pan­ies Bayer AG, Evonik Tech­no­lo­gies, and NGP Poly­mers Jena, as well as the Uni­ver­sit­ies of Würzburg and Jena. More than a thou­sand novel LNPs have been pro­duced to date and tested for their effic­acy and tolerability.

When admin­istered intra­ven­ously, they make it pos­sible to reach not only the liver but also other organs and to deliver RNAs to, for example, immune cells and heart muscle cells.

ISAR Bioscience is a found­ing mem­ber of the Munich Future Cluster C-NATM for the devel­op­ment of new nuc­leic acid-based ther­apies. In this con­text, fol­low­ing extens­ive joint pre­par­at­ory work, ISAR Bioscience sup­por­ted the form­a­tion oft he spin-off com­pany rnat­ics from the Tech­nical Uni­ver­sity of Munich. This is a joint effort to bring novel nuc­leic acid based ther­apies for severe lung infec­tions into the clinic.

ISAR Bioscience is part of the RNAmed gradu­ate pro­gram to train young sci­ent­ists in the emer­ging field of RNA medicine.

Together with Lud­wig Max­imilian Uni­ver­sity of Munich, ISAR Bioscience is lead­ing the effort to estab­lish a supra­re­gional net­work for RNA medi­cine. The RNA Val­ley is set to receive approx­im­ately 10 mil­lion euros in EU funding.

Weber C, Cza­plewska JA, Ulrich S. Schubert US, Klüp­fel J, Stef­fens E, Holthoff HP, Martin Ungerer M, Gut­mann MO, Ger­oli­metto G, Meinel L, Wang X, Michael Dirauf M, Ben­jamin Friebe B (2024) Copoly­mers and lipid com­pos­i­tions for lipid nan­o­particles. Pat­entan­mel­dung EP 24156905.2

Klüp­fel J, Stef­fens E, Holthoff HP, Ungerer M, Schuster F, Schubert US, Hol­ick C (2025)
Lipid com­pos­i­tion for lipid nan­o­particles (LNPs) pat­ent applic­a­tion WO2025257084A1