What we
are about

Dis­cover the state of the art of research on Alzheimer’s, heart fail­ure and immune dis­eases, and how ISAR Bioscience intends to advance regen­er­at­ive therapies.

What we are about

Dis­cover the state of the art of research on Alzheimer’s, heart fail­ure and immune dis­eases, and how ISAR Bioscience intends to advance regen­er­at­ive therapies.

Back­ground

ISAR Bioscience is a trans­la­tional com­pany devel­op­ing tech­no­lo­gies and new ther­apies for degen­er­at­ive dis­eases. We work closely with pub­lic research insti­tu­tions and com­pan­ies from the bio­tech­no­logy and phar­ma­ceut­ical indus­tries. We aim to build bridges between these insti­tu­tions and thus cre­ate a dir­ect link between basic research and new ther­apies and products. This is what we mean when we speak of “trans­la­tion”.

The dis­eases that we tar­get are all char­ac­ter­ized by a patho­lo­gical loss of organ func­tion – due to age­ing, insuf­fi­cient blood cir­cu­la­tion or a mal­func­tion­ing immune sys­tem. Examples are Alzheimer’s dis­ease and chronic car­diac fail­ure, which often occurs after a sur­viv­ing heart attack.
In these degen­er­at­ive dis­eases the nat­ural abil­ity of the organs to regen­er­ate from their own stem cells is no longer suf­fi­cient. This leads to the loss of cells and finally to the loss of organ function.
Such dis­eases play a major role world­wide. In most soci­et­ies they rep­res­ent the greatest bur­den of dis­ease, they are respons­ible for most hos­pital admis­sions and are the most fre­quent causes of death. If degen­er­at­ive dis­eases can be pushed back, the vis­ion of healthy age­ing comes within reach. 

Read more about such dis­eases and the state of research
Neuro­de­gen­er­at­ive dis­eases and Alzheimer’s disease

Dis­eases that make nerve cells die are a grow­ing prob­lem. They are so ser­i­ous because the brain’s abil­ity to regen­er­ate appears to be very lim­ited. It is there­fore import­ant to find strategies to pre­vent the death of nerve cells at an early stage. For this research ISAR Bioscience uses dis­ease mod­els derived from iPS cells. 

Myocar­dial infarc­tion and chronic heart failure

Car­di­ovas­cu­lar dis­eases are the lead­ing cause of death and hos­pital admis­sions. Again, often as a res­ult of a long devel­op­ment, it is a mat­ter of cell loss. This is the case, for example, after a heart attack, when cells die in the sup­ply area of a blocked blood ves­sel. ISAR Bioscience devel­ops new meth­ods to replace the lost cells and to pre­vent a patho­lo­gical trans­form­a­tion of the heart.

Dis­eases of the immune system

Our immune sys­tem pro­tects us against the pen­et­ra­tion of vir­uses and bac­teria. To do this, it must dis­tin­guish exactly what belongs to our body and what is for­eign to it. Some­times this dis­tinc­tion does not work and the immune sys­tem reacts either too strongly or too weakly. This con­trib­utes to many dis­eases. ISAR Bioscience looks for ways in which the immune sys­tem can find its bal­ance again.