What we
are about
are about
Discover the state of the art of research on Alzheimer’s, heart failure and immune diseases, and how ISAR Bioscience intends to advance regenerative therapies.
What we are about
Discover the state of the art of research on Alzheimer’s, heart failure and immune diseases, and how ISAR Bioscience intends to advance regenerative therapies.
Background
ISAR Bioscience is a translational company developing technologies and new therapies for degenerative diseases. We work closely with public research institutions and companies from the biotechnology and pharmaceutical industries. We aim to build bridges between these institutions and thus create a direct link between basic research and new therapies and products. This is what we mean when we speak of “translation”.
The diseases that we target are all characterized by a pathological loss of organ function – due to ageing, insufficient blood circulation or a malfunctioning immune system. Examples are Alzheimer’s disease and chronic cardiac failure, which often occurs after a surviving heart attack.
In these degenerative diseases the natural ability of the organs to regenerate from their own stem cells is no longer sufficient. This leads to the loss of cells and finally to the loss of organ function.
Such diseases play a major role worldwide. In most societies they represent the greatest burden of disease, they are responsible for most hospital admissions and are the most frequent causes of death. If degenerative diseases can be pushed back, the vision of healthy ageing comes within reach.
Neurodegenerative diseases and Alzheimer’s disease
Diseases that make nerve cells die are a growing problem. They are so serious because the brain’s ability to regenerate appears to be very limited. It is therefore important to find strategies to prevent the death of nerve cells at an early stage. For this research ISAR Bioscience uses disease models derived from iPS cells.
Myocardial infarction and chronic heart failure
Cardiovascular diseases are the leading cause of death and hospital admissions. Again, often as a result of a long development, it is a matter of cell loss. This is the case, for example, after a heart attack, when cells die in the supply area of a blocked blood vessel. ISAR Bioscience develops new methods to replace the lost cells and to prevent a pathological transformation of the heart.
Diseases of the immune system
Our immune system protects us against the penetration of viruses and bacteria. To do this, it must distinguish exactly what belongs to our body and what is foreign to it. Sometimes this distinction does not work and the immune system reacts either too strongly or too weakly. This contributes to many diseases. ISAR Bioscience looks for ways in which the immune system can find its balance again.