Neurodegenerative diseases

Investigating the symmetry of fibrillar plaques on AD mouse models confirms an asymmetric pattern, similar to Alzheimer’s disease patients, which translated into regional microglia activation.

Modulating Trem2 signaling through Trem2 antagonistic antibodies can alter microglia function and cause disease-relevant changes in Alzheimer’s disease.

sTREM2 correlates with microglia activation, and higher CSF sTREM2 levels can be linked to reduced cognitive decline and slower rates of Plaque accumulation in AD patients.