Asym­metry of Fib­ril­lar Plaque Bur­den in Amyl­oid Mouse Models

Invest­ig­at­ing the sym­metry of fib­ril­lar plaques on AD mouse mod­els con­firms an asym­met­ric pat­tern, sim­ilar to Alzheimer’s dis­ease patients, which trans­lated into regional microglia activation.

Asym­metry of Fib­ril­lar Plaque Bur­den in Amyl­oid Mouse Models.

Sacher C, Blume T, Beyer L, Biechele G, Sauer­beck J, Eck­en­weber F, Deuss­ing M, Focke C, Par­hizkar S, Lind­ner S, Gil­de­haus FJ, von Ungern-Stern­berg B, Bau­mann K, Tahirovic S, Klein­ber­ger G, Willem M, Haass C, Barten­stein P, Cum­ming P, Rominger A, Herms J, Brendel M. J Nucl Med. 2020 Dec;61(12):1825-1831. doi: 10.2967/jnumed.120.242750. Epub 2020 May 15. PMID: 32414948