Neutralizing antibodies and T cells against SARS-CoV2 and mutants, especially the delta mutant
We found that SARS-CoV-2 delta mutant antibody neutralisation was reduced compared to the Wuhan wild type (wt), as assessed in a novel inhibition assay with a finger prick blood drop. Strong T cell responses were present against wt and mutant SARS-CoV2 variants, including the delta (B.1.617.2) strain, in fully vaccinated individuals, whereas they were weaker 1 year after natural infection. Hence, immune responses after vaccination are stronger compared to those after naturally occurring infection, pointing out the need of vaccines to overcome the pandemic.
Richardson et al., SARS-COV2 mutant-specific T cells and neutralizing antibodies after vaccination and up to 1 year after infection. published in MedRXive on Sept 14, 2021; MS ID#: MEDRXIV/2021/262725; https://www.medrxiv.org/content/10.1101/2021.09.07.21262725v1