Development of innovative peptides

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Innovative peptides for the treatment of various autoimmune diseases such as rheumatoid arthritis

Innovative peptides have been conceived to treat several autoimmune diseases. These peptides act as tolerizing compounds, i. e. they re-establish tolerance towards the antigen. This therapeutic concept has been further developed and expanded to treat another autoimmune disease, rheumatoid arthritis (RA): Also for this disease indication, initial lead compounds have been identified in a disease model.

Wenhart C, Holthoff HP, Reimann A, Li Z, Faßbender J, Ungerer M. A fructosylated peptide derived from a collagen II T cell epitope for long-term treatment of arthritis (FIA-CIA) in mice. Scientific Reports 2021; 30;11(1):17345. doi: 10.1038/s41598-021–95193‑2

www.nature.com/articles/s41598-021–95193‑2