The Insti­tute of Func­tional Genomics

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The Insti­tute of Func­tional Geno­mics (IGF)

The Insti­tute of Func­tional Geno­mics (IGF) is a CNRS-INSERM-Uni­ver­sity of Mont­pel­lier joint rese­arch centre that deve­lops inno­va­tive stra­te­gies and methods to explore the mecha­nisms invol­ved in cell com­mu­ni­ca­tion and asso­cia­ted patho­lo­gies. Its rese­arch pro­grams range from struc­tu­ral ana­ly­sis of mole­cu­les to inte­gra­tive bio­logy and trans­la­tio­nal rese­arch, also pro­mo­ting bio­me­di­cal appli­ca­ti­ons and the emer­gence of new the­ra­pies and dia­gno­stic tools.

The team of Phil­ippe Ron­dard stu­dies GPCRs invol­ved in neu­ro­lo­gic and psych­ia­tric dis­or­ders. The group has iden­ti­fied and cha­rac­te­ri­zed the phar­ma­co­logy and the acti­va­tion pro­cess of the GPCRs for the two main neu­ro­trans­mit­ters i.e. glut­amate and GABA. Rese­arch pro­jects focus on the 8 dif­fe­rent mGlu recep­tors (mGluRs) and the sin­gle GABAB recep­tor that are excel­lent tar­gets for drug deve­lo­p­ment in the neu­ro­lo­gic and psych­ia­tric area.

Jean-Phil­lipe Pin is inter­na­tio­nally reco­gni­zed for his par­ti­ci­pa­tion in the dis­co­very of meta­bo­tro­pic glut­amate recep­tors, and his stu­dies rela­ted to the allos­teric modu­la­tion and acti­va­tion mecha­nism of this family of GPCRs. Over the recent years he deve­lo­ped inno­va­tive approa­ches to study cell sur­face recep­tors, inclu­ding bio­sen­sors, photo-switcha­ble ligands and nano­bo­dies as phar­ma­co­lo­gi­cal tools and poten­tial the­ra­peu­tic agents.

Sébas­tien Gra­nier has built a career app­ly­ing a wide variety of bio­phy­si­cal approa­ches to inves­ti­gate GPCR struc­ture and func­tion. After a suc­cessful post­doc in the labo­ra­tory of Brian Kobilka at Stan­ford elu­ci­da­ting opioid recep­tor struc­ture, he obtai­ned a ten­ure track posi­tion in France where he has deve­lo­ped bio­phy­si­cal approa­ches to study vaso­pres­sin V2 and glut­amate recep­tors. He is now a group lea­der in Mont­pel­lier Uni­ver­sity with a focus of deci­phe­ring the acti­va­tion mecha­nisms of GPCR and other mem­brane proteins.

The Team at IGF will con­tri­bute their exper­tise and tools in GPCR bio­logy to the UniS­ens project.