TSHR-spe­cific lymph­o­cytes in Graves´ dis­ease patient blood

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TSHR-spe­cific lymph­o­cytes in Graves´ dis­ease patient blood

 

Novel major his­to­com­pat­ib­il­ity com­plex class II (MHC II) tet­ra­mers iden­ti­fied spe­cific T lymph­o­cytes for thyroid stim­u­lat­ing hor­mone recept­ors (TSHR) in hyper­thyroid mice and in human blood cells from Graves´ patients. These assays may con­trib­ute to meas­ure both, dis­ease sever­ity and effects of novel immune ther­apies in future invest­ig­a­tions of Graves´ disease.

Degen H, Gav­vovidis J, Blanken­stein T, Uhland K, Ungerer M. TSHR-spe­cific lymph­o­cytes in Ad-TSHR-immun­ized nat­ive and HLA-DR3-trans­genic mice and in Graves´ dis­ease patient blood. Thyroid 2020, online preprint
doi: 10.1089/thy.2020.0338; https://doi.org/10.1089/thy.2020.0338