TSHR-specific lymphocytes in Graves´ disease patient blood
Novel major histocompatibility complex class II (MHC II) tetramers identified specific T lymphocytes for thyroid stimulating hormone receptors (TSHR) in hyperthyroid mice and in human blood cells from Graves´ patients. These assays may contribute to measure both, disease severity and effects of novel immune therapies in future investigations of Graves´ disease.
Degen H, Gavvovidis J, Blankenstein T, Uhland K, Ungerer M. TSHR-specific lymphocytes in Ad-TSHR-immunized native and HLA-DR3-transgenic mice and in Graves´ disease patient blood. Thyroid 2020, online preprint
doi: 10.1089/thy.2020.0338; https://doi.org/10.1089/thy.2020.0338