Sci­ent­ist – Neuro­de­gen­er­a­tion (gn)


ISAR Bioscience GmbH is a trans­la­tional research com­pany in Planegg near Munich, sup­por­ted by the Free State of Bavaria.

Our research focuses on (auto-)immune dis­eases, degen­er­at­ive dis­eases of the brain (Alzheimer’s) and heart dis­eases (infarc­tion, car­diac fail­ure). We use human induced pluri­po­tent stem cell (iPSC) tech­no­lo­gies to develop dis­ease mod­els for the dis­cov­ery of novel drugs and cell ther­apies. In doing so, we enter into stra­tegic part­ner­ships with research insti­tu­tions and indus­trial companies

To expand our “Neuro­de­gen­er­a­tion Pro­gram” team, we are filling the pos­i­tion full-time as of 01.04.2023

Sci­ent­ist – Neuro­de­gen­er­a­tion (gn)

Primary respons­ib­il­it­ies

  • Develop a robust, repro­du­cible and scal­able 2D/3D co-cul­ture sys­tem to model human Alzheimer’s dis­ease patho­logy using cells derived from induced pluri­po­tent stem cell (iPSC)
  • Estab­lish robust and scal­able assays to mon­itor activ­a­tion status of microglia within the 2D/3D co-cul­ture sys­tem using a com­bin­a­tion of ima­ging tech­no­lo­gies and bio­chem­ical assays
  • Develop, optim­ize and per­form stand­ard­ized pro­to­cols to com­pre­hens­ively char­ac­ter­ize neur­ons, microglia and other rel­ev­ant dis­ease model cells within a cel­lu­lar co-cul­ture model
  • Crit­ic­ally ana­lyze and inter­pret data and define real­istic timelines for studies
  • Work closely with and com­mu­nic­ate res­ults to internal teams as well as to external partners


  • Ph.D. in Neur­os­cience, Stem Cell Bio­logy, (Neuro)Immunology or related field
  • Exper­i­ence using iPSC-based technologies
  • Exper­i­ence in neur­os­cience and char­ac­ter­iz­a­tion of neuro­de­gen­er­at­ive models
  • Exper­i­ence in deriv­ing and util­iz­ing neur­onal cul­tures for cel­lu­lar mod­el­ling of dis­ease (e.g. iPSC-derived neur­onal cul­tures, organoids, microglia, astro­cytes, etc)
  • Exper­i­ence in embed­ding and cul­tur­ing cells in a 3D mat­rix (e.g. mat­ri­gel, hydro­gels, brain-on-a-chip) is a plus
  • Exper­i­ence in neuroim­mun­o­logy and/or neuroin­flam­ma­tion is a plus
  • Good com­mand of Eng­lish (both writ­ten and spoken); Know­ledge of Ger­man is an advantage

Our offer

We offer the spe­cial oppor­tun­ity to help shape the devel­op­ment of a new research com­pany in an inter­dis­cip­lin­ary team with pion­eer­ing spirit. You will be given excit­ing tasks and per­sonal devel­op­ment. The salary will depend on qual­i­fic­a­tions and pro­fes­sional exper­i­ence and is cal­cu­lated in accord­ance with the civil ser­vice salary scales. The pos­i­tion is ini­tially temporary.


Please send your cover let­ter and com­plete applic­a­tion doc­u­ments with CV, references/ recom­mend­a­tion let­ter to . Please indic­ate the title of the job advert­ise­ment in the sub­ject line. Altern­at­ively you can use the Applic­a­tion Form below.

  • Dr. Chris­ti­ane Schiegerl
    Dr. Chris­ti­ane Schiegerl

    Please do not hes­it­ate to con­tact me if you have any questions.


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Please send us your applic­a­tion doc­u­ments with CV, ref­er­ences or let­ters of recom­mend­a­tion as a PDF file.

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